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Crizalk 250mg Capsule

Prescription Required
prescription

Salt Composition

Manufacturer

PFIZER LTD

Origin of Medicine

United States of America

₹84400.00

    MRP:₹106602.30
Save ₹ 22202.3 (21%)
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Overview & Usage

Overview Of Crizalk 250mg Capsule

Crizalk 250mg Capsule contains Crizotinib, an antineoplastic medicine belonging to the class of tyrosine kinase inhibitors. It is primarily prescribed for patients with ALK-positive non-small cell lung cancer (NSCLC) that is locally advanced or has spread to other parts of the body. This targeted therapy works by blocking abnormal proteins that promote cancer cell growth, helping slow disease progression and improve treatment outcomes. Crizalk is used only under the supervision of an oncologist and is not recommended for children or adolescents below 18 years of age.

Before starting treatment, patients should inform their doctor about any history of heart, liver, kidney, or stomach disorders. Special precautions are required for patients with vision problems, abnormal ECG results, or low blood cell counts. Proper sun protection is advised during treatment due to increased sensitivity to sunlight.


Usage Of Crizalk 250mg Capsule

Crizalk 250mg Capsule is used for the treatment of:

1. Anaplastic Lymphoma Kinase (ALK) positive non-small cell lung cancer (NSCLC)

How Crizalk 250mg Capsule Works

Crizalk 250mg Capsule works by inhibiting the activity of the ALK (anaplastic lymphoma kinase) protein, which is abnormally active in certain lung cancers. By blocking this protein, Crizotinib prevents cancer cells from multiplying and spreading. This targeted mechanism helps slow tumor growth while limiting damage to healthy cells, making it an effective option for ALK-positive NSCLC.


Side Effects Of Crizalk 250mg Capsule

Side Effects of Crizalk 250mg Capsule

Like all medications, Crizalk 250mg Capsule may cause side effects. However, not everyone will experience them.

Serious Side Effects (Seek immediate medical attention):

  • Vision loss or visual disturbances
  • Severe abdominal pain
  • Lung inflammation or breathlessness
  • Low heart rate
  • Swelling of lungs
  • Significant drop in white blood cell count

Common Side Effects (Usually mild and temporary):

  • Nausea or vomiting
  • Fatigue and weakness
  • Constipation
  • Decreased appetite
  • Sensitivity to sunlight
  • Taste disturbances
  • Sensitivity to sunlight
  • Increased liver enzymes
  • Nerve-related symptoms (tingling or numbness)

Dosage Of Crizalk 250mg Capsule

The usual recommended dose of Crizalk is 250mg taken orally twice daily, preferably at the same time each day. Capsules should be swallowed whole with water and must not be crushed, chewed, or opened. The exact dosage and duration of treatment are determined by your doctor based on your medical condition and response to therapy. Never adjust the dose or stop treatment without medical advice.


Safety Advice for Crizalk 250mg Capsule

Breast Feeding

Breast Feeding

Unsafe

Breastfeeding is not recommended during treatment, as the medicine may pass into breast milk and harm the baby.

Breast Feeding

Alcohol

Consult Your Doctor

The safety of alcohol use with Crizalk is not well established. Consult your doctor before consuming alcohol.

Breast Feeding

Lungs

Safe

Inform your doctor immediately if you develop breathing difficulties, cough, fever, or signs of lung inflammation.

Breast Feeding

Driving

Unsafe

Avoid driving or operating machinery, as Crizalk may cause dizziness or fatigue.

Breast Feeding

Pregnancy

Unsafe

Crizalk 250mg Capsule should not be used during pregnancy, as it may cause harm to the unborn baby. Effective non-hormonal contraception is advised during treatment and for at least 90 days after stopping the medicine.

Storage Advice Of Crizalk 250mg Capsule

  • Store at room temperature between 20°C to 25°
  • Keep in the original container
  • Keep out of reach of children and pets.
  • Expert Tips

  • Take Crizalk 250mg Capsule as advised by your doctor at the same time each day for better treatment effectiveness.
  • Regular check-ups help monitor your response to the therapy and manage any side effects.
  • Report vision changes, fatigue, nausea, or swelling to your doctor promptly.
  • Eat balanced meals, stay hydrated, and get enough rest during treatment.

  • FAQs about Crizalk 250mg Capsule

    Q1. How does Crizalk 250mg Capsule specifically target ALK-positive lung cancer?

    Crizalk contains crizotinib, which selectively inhibits the abnormal anaplastic lymphoma kinase (ALK) protein that drives cancer cell growth in ALK-positive NSCLC. By blocking this signaling pathway, Crizalk slows tumor growth and limits cancer spread while sparing most healthy cells.

    Q2. Is genetic testing required before starting Crizalk 250mg treatment?

    Yes. Crizalk is effective only in patients whose tumors test positive for the ALK gene rearrangement. Molecular or genetic testing is essential before initiating treatment to ensure the medicine will be effective.

    Q3. Can Crizalk 250mg Capsule be used long-term, and how is treatment monitored?

    Crizalk may be used for long-term treatment as long as it remains effective and well tolerated. Regular monitoring, including blood counts, liver function tests, ECGs, and eye examinations, is required to ensure safety during ongoing therapy.

    Q4. What precautions should patients take regarding sun exposure while on Crizalk?

    Crizalk can increase sensitivity to sunlight, raising the risk of sunburn. Patients should use sunscreen, wear protective clothing, and avoid prolonged sun exposure while receiving treatment.

    Q5. Why is hormonal birth control not recommended during Crizalk treatment?

    Crizalk can reduce the effectiveness of oral contraceptives. Patients should use reliable non-hormonal contraception during treatment and for at least 90 days after stopping the medicine to prevent pregnancy.

    Key Fact Box

    Active ingredient Crizotinib
    Pharmacologic class Tyrosine Kinase Inhibitor
    Medication category ANTI NEOPLASTICS
    Dosage forms Capsule

    Medical Advisory

      The information on the Phoenix Pharmex website is shared for educational purposes only and is not a substitute for professional medical advice or treatment. Always consult a doctor for any health-related questions. Please avoid self diagnosis or delaying medical care based on this content. Our mission is to support informed decisions not replace professional medical guidance.

    DOSAGE

    Frequently Asked Questions

    Azadine 100mg Injection contains Azacitidine which belongs to the group of medicines called Anticancer agents. It is used in adults to treat all sub-types of myelodysplastic syndromes (MDS; group of cancers associated with blood and bone marrow) and certain types of blood cancers known as Chronic myelomonocytic leukemia (CMML) and acute myeloid leukemia (AML).

    Azadine 100mg Injection is typically used in adults who cannot undergo stem cell transplantation. It may be also used to treat other conditions, as determined by the doctor.

    Azadine Injection is given as an injection under the medical supervision of a doctor. Your doctor will decide what dose is necessary and how often you need to take it. This will depend on what you are being treated for and may change from time to time. You should take it exactly as your doctor has advised.

    You must inform your doctor before taking any vaccination while on treatment with this medicine. Regular blood tests are required to check your blood cells along with the heart, liver, and kidney.

    Before taking it, tell your doctor if you have liver, or kidney problems or are taking any medicines to treat infections. Many other medicines can affect, or be affected by, this medicine so let your doctor know all medications you are using.

    MEDICINAL USE OF AZADINE 100MG INJECTION

    Azadine 100mg Injection is an anticancer medication. It works by blocking the actions of certain enzymes (DNA/RNA methyltransferase) within the cancer cells that is required for the cells to grow and multiply. It also reduces the production of new genetic material (RNA and DNA) within the cells. As a result, it prevents abnormal cell division within the body, slows down the growth of cancer cells and helps the bone marrow to produce normal blood cells.

    It is used to treat:

    • All sub-types of myelodysplastic syndromes (MDS; group of cancers associated with blood and bone marrow)
    • Chronic myelomonocytic leukemia (CMML; blood cancer of monocytes)
    • Acute myeloid leukemia (AML; blood cancer of WBC)
    SIDE EFFECTS OF AZADINE 100MG INJECTION

    Side effects are unwanted symptoms caused by medicines. Even though all drugs cause side effects, not everyone gets them.

    • Low RBC count causing anemia, tiredness and pale skin
    • Increased infections, lung infections (pneumonia), fever and chills
    • Increased bleeding tendency due to low blood platelet counts
    • Nausea, vomiting
    • Diarrhea, constipation, loss of appetite, stomach pain
    • Tiredness, weakness
    • Injection site reactions (such as pain, redness and swelling or lump formation)
    • Joint pain, muscle pain, skin rashes with redness and itching
    • Sore nose and throat, cold sores, sinnusitis
    • Headache, dizziness
    • Trouble sleeping (insomnia)
    • Nosebleeds, bleeding gums
    • Weight loss
    • Urinary tract infections
    • Ulcers of mouth or tongue
    • High or low blood pressure
    • Anxiety, confusion
    • Hair loss, dehydration
    • Oral fungal infection
    • Sleepiness
    • Fluid around the lungs or heart
    DOSAGE OF AZADINE 100MG INJECTION
    • The dose of Azacitidine is determined by the patient's height, weight, and general condition. It is given under the skin of your thigh, stomach, or upper arm.
    • Minimum of 4 to 6 cycles; may continue treatment if the patient continues to benefit.
    • Since Azadine 100 mg Injection is administered in the hospital or clinical setting by a qualified health care professional, the likelihood of a missed dose is very low.
    • Since Azadine 100 mg Injection is administered in the hospital or clinical setting by a qualified healthcare professional, the likelihood of an overdose is very low. However, emergency medical treatment will be initiated by the doctor if an overdose is suspected.

    Ques 1: What is the use of AZADINE 100MG INJECTION?

    Ans :AZADINE 100MG INJECTION is used in adults to treat all sub-types of myelodysplastic syndromes (MDS; group of cancers associated with blood and bone marrow) and certain types of blood cancers known as Chronic myelomonocytic leukemia (CMML) and acute myeloid leukemia (AML).

    Ques 2: How does AZADINE 100MG INJECTION works?

    Ans :AZADINE 100MG INJECTION is an anticancer medication. It works by blocking the actions of certain enzymes (DNA/RNA methyltransferase) within the cancer cells that is required for the cells to grow and multiply. It also reduces the production of new genetic material (RNA and DNA) within the cells. As a result, it prevents abnormal cell division within the body, slows down the growth of cancer cells and helps the bone marrow to produce normal blood cells.

    Ques 3: Can I take AZADINE 100MG INJECTION during breastfeeding?

    Ans :No. AZADINE 100MG INJECTION is not recommended for use in breast-feeding women. Therefore, inform your doctor before receiving it.

    Ques 4: Can AZADINE 100MG INJECTION increase the risk of infections?

    Ans :AZADINE 100MG INJECTION may cause a drop in the number of white blood cells in the body and may weaken your immune system. As a result, you may be at a greater risk of getting infected while receiving AZADINE 100MG INJECTION. To avoid this, your doctor will regular monitor your blood counts as a precaution. However, inform your doctor if you experience any signs of infection such as fever.

    Ques 5: Can the use of AZADINE 100MG INJECTION make me feel tired?

    Ans :Yes. AZADINE 100MG INJECTION may make you feel tired easily. This is because, it reduces the levels of red blood cells in your blood and may make you anemic. Consult your doctor if you experience tiredness after receiving AZADINE 100MG INJECTION. Tiredness can also occur if you have any pre-existing disease conditions such as liver or kidney impairment while receiving this medicine.

    Ques 6: Can I drive a car after receiving AZADINE 100MG INJECTION?

    Ans :AZADINE 100MG INJECTION may make you feel tired or weak. Therefore, do not drive or operate any heavy tools or machines if your ability is affected by AZADINE 100MG INJECTION.

    Ques 7: How AZADINE 100MG INJECTION is administered?

    Ans :AZADINE 100MG INJECTION will be given to you only by a doctor or a nurse beneath the skin (subcutaneously) of thighs, arms or abdomen.

    Ques 8: How to control nausea caused due to AZADINE 100MG INJECTION?

    Ans :Generally, anticancer medicines are associated with uncontrollable nausea and vomiting. To avoid this, your doctor would prescribe a suitable medicine to control them along with AZADINE 100MG INJECTION. If not, consult your doctor for a suitable anti-emetic medicine. Do not self-treat nausea.

    Overview Of Crizalk 250mg Capsule

    Crizalk 250mg Capsule contains Crizotinib, an antineoplastic medicine belonging to the class of tyrosine kinase inhibitors. It is primarily prescribed for patients with ALK-positive non-small cell lung cancer (NSCLC) that is locally advanced or has spread to other parts of the body. This targeted therapy works by blocking abnormal proteins that promote cancer cell growth, helping slow disease progression and improve treatment outcomes. Crizalk is used only under the supervision of an oncologist and is not recommended for children or adolescents below 18 years of age.

    Before starting treatment, patients should inform their doctor about any history of heart, liver, kidney, or stomach disorders. Special precautions are required for patients with vision problems, abnormal ECG results, or low blood cell counts. Proper sun protection is advised during treatment due to increased sensitivity to sunlight.


    Usage Of Crizalk 250mg Capsule

    Crizalk 250mg Capsule is used for the treatment of:

    1. Anaplastic Lymphoma Kinase (ALK) positive non-small cell lung cancer (NSCLC)

    How Crizalk 250mg Capsule Works

    Crizalk 250mg Capsule works by inhibiting the activity of the ALK (anaplastic lymphoma kinase) protein, which is abnormally active in certain lung cancers. By blocking this protein, Crizotinib prevents cancer cells from multiplying and spreading. This targeted mechanism helps slow tumor growth while limiting damage to healthy cells, making it an effective option for ALK-positive NSCLC.


    Side Effects Of Crizalk 250mg Capsule

    Side Effects of Crizalk 250mg Capsule

    Like all medications, Crizalk 250mg Capsule may cause side effects. However, not everyone will experience them.

    Serious Side Effects (Seek immediate medical attention):

    • Vision loss or visual disturbances
    • Severe abdominal pain
    • Lung inflammation or breathlessness
    • Low heart rate
    • Swelling of lungs
    • Significant drop in white blood cell count

    Common Side Effects (Usually mild and temporary):

    • Nausea or vomiting
    • Fatigue and weakness
    • Constipation
    • Decreased appetite
    • Sensitivity to sunlight
    • Taste disturbances
    • Sensitivity to sunlight
    • Increased liver enzymes
    • Nerve-related symptoms (tingling or numbness)

    Dosage Of Crizalk 250mg Capsule

    The usual recommended dose of Crizalk is 250mg taken orally twice daily, preferably at the same time each day. Capsules should be swallowed whole with water and must not be crushed, chewed, or opened. The exact dosage and duration of treatment are determined by your doctor based on your medical condition and response to therapy. Never adjust the dose or stop treatment without medical advice.


    Safety Advice for Crizalk 250mg Capsule

    Breast Feeding

    Breast Feeding

    Unsafe

    Breastfeeding is not recommended during treatment, as the medicine may pass into breast milk and harm the baby.

    Breast Feeding

    Alcohol

    Consult Your Doctor

    The safety of alcohol use with Crizalk is not well established. Consult your doctor before consuming alcohol.

    Breast Feeding

    Lungs

    Safe

    Inform your doctor immediately if you develop breathing difficulties, cough, fever, or signs of lung inflammation.

    Breast Feeding

    Driving

    Unsafe

    Avoid driving or operating machinery, as Crizalk may cause dizziness or fatigue.

    Breast Feeding

    Pregnancy

    Unsafe

    Crizalk 250mg Capsule should not be used during pregnancy, as it may cause harm to the unborn baby. Effective non-hormonal contraception is advised during treatment and for at least 90 days after stopping the medicine.

    Storage Advice Of Crizalk 250mg Capsule

  • Store at room temperature between 20°C to 25°
  • Keep in the original container
  • Keep out of reach of children and pets.
  • Expert Tips

  • Take Crizalk 250mg Capsule as advised by your doctor at the same time each day for better treatment effectiveness.
  • Regular check-ups help monitor your response to the therapy and manage any side effects.
  • Report vision changes, fatigue, nausea, or swelling to your doctor promptly.
  • Eat balanced meals, stay hydrated, and get enough rest during treatment.

  • FAQs about Crizalk 250mg Capsule

    Q1. How does Crizalk 250mg Capsule specifically target ALK-positive lung cancer?

    Crizalk contains crizotinib, which selectively inhibits the abnormal anaplastic lymphoma kinase (ALK) protein that drives cancer cell growth in ALK-positive NSCLC. By blocking this signaling pathway, Crizalk slows tumor growth and limits cancer spread while sparing most healthy cells.

    Q2. Is genetic testing required before starting Crizalk 250mg treatment?

    Yes. Crizalk is effective only in patients whose tumors test positive for the ALK gene rearrangement. Molecular or genetic testing is essential before initiating treatment to ensure the medicine will be effective.

    Q3. Can Crizalk 250mg Capsule be used long-term, and how is treatment monitored?

    Crizalk may be used for long-term treatment as long as it remains effective and well tolerated. Regular monitoring, including blood counts, liver function tests, ECGs, and eye examinations, is required to ensure safety during ongoing therapy.

    Q4. What precautions should patients take regarding sun exposure while on Crizalk?

    Crizalk can increase sensitivity to sunlight, raising the risk of sunburn. Patients should use sunscreen, wear protective clothing, and avoid prolonged sun exposure while receiving treatment.

    Q5. Why is hormonal birth control not recommended during Crizalk treatment?

    Crizalk can reduce the effectiveness of oral contraceptives. Patients should use reliable non-hormonal contraception during treatment and for at least 90 days after stopping the medicine to prevent pregnancy.

    Key Fact Box

    Active ingredient Crizotinib
    Pharmacologic class Tyrosine Kinase Inhibitor
    Medication category ANTI NEOPLASTICS
    Dosage forms Capsule

    Medical Advisory

      The information on the Phoenix Pharmex website is shared for educational purposes only and is not a substitute for professional medical advice or treatment. Always consult a doctor for any health-related questions. Please avoid self diagnosis or delaying medical care based on this content. Our mission is to support informed decisions not replace professional medical guidance.

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